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Jia-Heng Tan Selected Research

quindoline

8/2018Design, Synthesis, and Evaluation of Novel p-(Methylthio)styryl Substituted Quindoline Derivatives as Neuroblastoma RAS (NRAS) Repressors via Specific Stabilizing the RNA G-Quadruplex.
12/2017Interaction of Quindoline derivative with telomeric repeat-containing RNA induces telomeric DNA-damage response in cancer cells through inhibition of telomeric repeat factor 2.
1/2017New Disubstituted Quindoline Derivatives Inhibiting Burkitt's Lymphoma Cell Proliferation by Impeding c-MYC Transcription.
6/2010Turning off transcription of the bcl-2 gene by stabilizing the bcl-2 promoter quadruplex with quindoline derivatives.

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Jia-Heng Tan Research Topics

Disease

23Neoplasms (Cancer)
12/2021 - 05/2009
5Alzheimer Disease (Alzheimer's Disease)
05/2015 - 09/2011
1Mitochondrial Diseases (Mitochondrial Disease)
01/2022
1Body Weight (Weight, Body)
04/2020
1Obesity
04/2020
1Melanoma (Melanoma, Malignant)
01/2020
1Bloom Syndrome
01/2019
1Neuroblastoma
08/2018
1Burkitt Lymphoma (Burkitt's Lymphoma)
01/2017
1Inclusion Body Myositis
07/2014
1Fibrosarcoma
07/2014
1Neoplasm Metastasis (Metastasis)
07/2014
1Myotonic Dystrophy (Dystrophia Myotonica)
07/2014
1Wounds and Injuries (Trauma)
07/2014
1Leukemia
05/2011

Drug/Important Bio-Agent (IBA)

7LigandsIBA
01/2020 - 05/2009
5Pharmaceutical PreparationsIBA
01/2020 - 12/2010
5Biological ProductsIBA
01/2015 - 12/2010
4Proteins (Proteins, Gene)FDA Link
01/2019 - 03/2012
4quindolineIBA
08/2018 - 06/2010
3Telomerase (Telomerase Reverse Transcriptase)IBA
01/2020 - 05/2009
2DNA (Deoxyribonucleic Acid)IBA
01/2019 - 11/2017
2GuanineIBA
08/2018 - 11/2015
2RNA (Ribonucleic Acid)IBA
08/2018 - 12/2017
2Nucleic AcidsIBA
02/2018 - 07/2014
2BerberineIBA
11/2015 - 03/2012
2CurcuminIBA
01/2015 - 09/2011
1Transcription Factors (Transcription Factor)IBA
01/2022
1Mitochondrial DNA (mtDNA)IBA
12/2021
1CholesterolIBA
04/2020
1ImidazolesIBA
01/2020
1imidazoleIBA
01/2020
1benzothiazoleIBA
01/2020
1isaindigotoneIBA
01/2019
1Messenger RNA (mRNA)IBA
08/2018
1Terpenes (Terpenoids)IBA
11/2017
1Small Molecule LibrariesIBA
11/2017
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
01/2017
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
01/2017
1Cell ExtractsIBA
03/2016
1Polyethylene Glycols (Polyethylene Glycol)FDA LinkGeneric
03/2016
1PoisonsIBA
01/2016
1trioctyl phosphine oxide (TOPO)IBA
01/2016
1A-Form DNA (A-DNA)IBA
11/2015
1DisintegrinsIBA
05/2015
1Amyloid (Amyloid Fibrils)IBA
05/2015
1Peptides (Polypeptides)IBA
05/2015
1Metalloproteases (Metalloproteinases)IBA
05/2015
1Ribosomal RNAIBA
10/2014
1Ribosomal DNA (rDNA)IBA
10/2014
1RNA Polymerase I (Polymerase I, RNA)IBA
10/2014
1QuinazolinesIBA
10/2014
1LuciferasesIBA
07/2014
1Heterogeneous-Nuclear Ribonucleoprotein KIBA
07/2014
1ChromatinIBA
07/2014
1Carrier Proteins (Binding Protein)IBA
07/2014
1RibonucleoproteinsIBA
07/2014
1Antineoplastic Agents (Antineoplastics)IBA
08/2011

Therapy/Procedure

5Therapeutics
10/2020 - 01/2017